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. 2021 Dec 3;16:7943–7957. doi: 10.2147/IJN.S335438

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© 2021 Wang et al.

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ADSCs-hEVs promote the expression and secretion of extracellular matrix and growth factors in HF. (A) QRT-PCR analysis of mRNA levels, including bFGF, MMP1, VEGF, TGF-β. (B) The proliferation of cells by Edu assays. *, vs ADSCs-EVs; #, vs Ctrl; (C) Western-blot analysis of protein levels of p-akt induced by different concentrations of control, ADSCs-EVs, ADSCs-hEVs and ADSCs-cEVs. LY294002 inhibit the activation of PI3K/ AKT induced by control, ADSCs-EVs, ADSCs-hEVs and ADSCs-cEVs. Data are represented as mean ± SD. *, vs ADSCs-hEVs+Ly; #, vs ADSCs-EVs+Ly; +, vs ADSCs-cEVs+Ly; n = 3. *P < 0.05, **P < 0.01, ***P < 0.0001, ^#P < 0.05,^##P < 0.001, ^###P < 0.0001, ⁺P < 0.05.