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. 2021 Dec 3;16:7943–7957. doi: 10.2147/IJN.S335438

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© 2021 Wang et al.

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ADSCs-hEVs promote the proliferation and migration of cells via the PI3K/AKT. (A) Edu assay showed that ADSCs-hEVs-treated HF proliferation was suppressed by inhibitors LY294002, compared with ADSCs-EVs. *, vs ADSCs-hEVs+Ly; #, vs ADSCs-EVs+Ly; +, vs ADSCs-cEVs+Ly; (B) QRT-PCR analysis of wound tissue mRNA level 14 days after operation, including bFGF, COLI, PDGF, VEGF, TGF-β. (C) After ADSCs-hEVs-treated 0, 3, 7 and 14 days were taken. Data are represented as mean ± SD. *, vs DW+EVs; #, vs DW+PBS; ns, vs DW+PBS; n = 3. *P < 0.05, **P < 0.01, ***P < 0.0001, ^#P < 0.05, ^##P < 0.01, ^####P < 0.00001, ⁺⁺⁺P < 0.0001. Bars, 100μm.