TABLE 2.
Comparison of vaccine‐induced SARS‐CoV‐2‐specific T‐cell responses generated by healthy donors and cancer patients
| Time‐point | Cohort | IFN‐γ | IL−2 | ||||
|---|---|---|---|---|---|---|---|
| NR | R | p value | NR | R | p value | ||
| PRE | HD | 68 | 46 |
*** p = 0·0009 |
87 | 21 |
NS p = 0·23 |
| Cancer | 57 | 11 | 34 | 4 | |||
| V1 | HD | 12 | 116 |
**** p < 0·0001 |
11 | 90 |
**** p < 0·0001 |
| Cancer | 29 | 27 | 33 | 32 | |||
| V2 | HD | 3 | 101 |
* p = 0·034 |
5 | 107 |
NS p = 0·29 |
| Cancer | 7 | 49 | 5 | 48 | |||
| 3 month | HD | 0 | 13 |
NS p = 0·18 |
2 | 10 |
NS p = 0·61 |
| Cancer | 9 | 39 | 5 | 46 | |||
Vaccination response rates (NR = no response, R = response) in terms of positive T‐cell (IFN‐γ, IL‐2) response amongst each cohort are shown. p values indicate results from Fisher's exact test.
*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.