Table 2.
IC50 values of identified cysteine protease inhibitors against PLPro
|
Name |
IC50 (μM)[a] |
|---|---|
|
NSC18058 |
n.d. |
|
Leupeptin |
n.d. |
|
HY‐17541 A |
n.d. |
|
HY‐17541 |
n.d. |
|
PMSF |
n.d. |
|
EP1013 |
n.d. |
|
S130 |
35.0±1.4 |
|
Petesicatib |
n.d. |
|
Tauroursodeoxycholate |
n.d. |
|
Emricasan |
n.d. |
|
N‐Ethylmaleimide |
n.d. |
|
CA‐074 |
n.d. |
|
CA‐074 methyl ester |
n.d. |
|
Z‐VAD(OMe)‐FMK |
n.d. |
|
Aloxistatin |
n.d. |
|
Q‐VD‐OPh |
n.d. |
|
H‐Arg‐4 MβNA |
n.d. |
|
LY 3000328 |
n.d. |
|
BOC‐D‐FMK |
n.d. |
|
Z‐DEVD‐FMK |
n.d. |
|
E‐64 |
n.d. |
|
Balicatib |
n.d. |
|
Odanacatib |
n.d. |
|
Belnacasan |
n.d. |
|
Calpetin |
n.d. |
|
E 64c |
n.d. |
|
3‐Epiursolic Acid |
n.d. |
|
MDL‐28170 |
n.d. |
|
Chelidonic acid |
n.d. |
|
MG‐101 |
n.d. |
|
Z‐VAD‐FMK |
n.d. |
|
OT‐82 |
n.d. |
|
IKarisoside A |
n.d. |
|
Wedelolactone |
n.d. |
|
Phenoxodiol |
n.d. |
|
2‐Cyanopyrimidine |
n.d. |
|
Z‐WEHD‐FMK |
n.d. |
[a] n.d.: not determined.