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. 2021 Nov 13;111(3):585–594. doi: 10.1002/cpt.2463

Table 4.

Parameter estimates for simultaneous parent‐metabolite PK model fitting to tizoxanide and tizoxanide glucuronide plasma concentration data

CLTIZ/F TIZ, L/h V TIZ/F TIZ, L K a, h−1 CLMET/(F TIZ*F MET), L/h V MET/(F TIZ*F MET), L/h
Parameter estimate 3.95 64.99 0.45 5.88 12.71
% RSE* 3.64 8.15 14.20 3.70 12.67

CLMET, metabolite clearance; CLTIZ, tizoxanide clearance; FMET, bioavailability of tizoxanide; FTIZ, tizoxanide glucoronide; K a, absorption rate constant; PK, pharmacokinetic; RSE, relative standard error.