TABLE 3.

Factors associated with a negative antibody response after vaccination in KT recipients

	Univariate			Multivariate
	OR	95% CI	p-value	OR	95% CI	p-value
Sociodemographics
Age (years)	1.035	0.99–1.07	.06	1.03	0.98–1.074	.16
Sex (ref: female)	0.53	0.22–1.27	.15
Body mass index (kg/m2)	1.034	0.96–1.11	.36
Seasonal vaccine (ref: no)	0.85	0.33–2.22	.75
Darbepoetin treatment (ref: no)	8.80	1.74–44.46	.009	6.02	0.89–34.35	.17
Vitamin D supplementation (ref: no)	1.50	0.52–4.92	.44
Comorbidities
Hypertensiona	—	—	—
Diabetes mellitus	1.08	0.45–2.59	.84
Cardiovascular disease	1.05	0.43–2.58	.90
Pulmonary disease	1.50	0.52–4.29	.44
Underlying diabetic nephropathy	2.53	0.50–12.70	.25
Blood tests
White blood cells (×103 U/µl)	0.83	0.69–1.013	.12
T lymphocytes (×103 U/µl)	0.68	0.42–1.10	.11
C-reactive protein (mg/dl)	1.19	0.77–1.82	.41
Albumin (g/dl)	0.77	0.30–2.00	.60
Transplantation characteristics
Time after transplantation (months)	0.99	0.98–1.01	.10
Transplantation >1 year	0.45	0.17–1.15	.09	0.42	0.14–1.12	.11
Transplantation >6 months	0.37	0.12–1.12	.07	0.29	0.08–1.01	.05
Serum creatinine (mg/dl)b	2.17	1.12–4.22	.02	1.60	0.75–3.40	.22
eGFR (ml/min per 1.73 m2)b	0.97	0.95–0.99	.02	0.98	0.96–1.01	.30
Immunosuppression treatment
Prednisonea	—	—	—
Mycophenolic acid	1.48	0.62–3.54	.37
Tacrolimus or cyclosporin A	2.56	0.27–23.94	.41
Tacrolimus dose (mg/kg/day)	0.013	0.01–22.28	.38
Tacrolimus blood levels (ng/ml)	1.97	0.92–1.03	.45
Everolimus	1.98	0.36–2.66	.97
Everolimus dose (mg/kg/day)	0.11	0.01–3.99	.45
Everolimus blood levels (ng/ml)	1.65	0.74–3.66	.21

Bold values indicate statistically significant p values (p < .05).

Abbreviations: CI, confidence interval; eGFR, estimated glomerular filtration rate; KT, kidney transplant; OD, odds ratio.

^aImpossible calculation, as patients without prednisone and a negative response were = 0.

^bDifferent models, using either serum creatinine or eGFR.