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. 2021 Nov 5;60(49):25966–25972. doi: 10.1002/anie.202110702

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© 2021 Wiley‐VCH GmbH

This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.

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Validation of the Simoa assay using the orthogonal pseudovirus neutralization assay. A) 28 samples from patients with COVID‐19 were used to correlate the Simoa and the pseudovirus neutralization assays. The Pearson correlation coefficient was 0.92. B) Patient samples over time were measured using both the Simoa and the pseudovirus neutralization assays and show good agreement (top). Anti‐spike IgM and anti‐spike IgG levels were measured using Simoa and correlated with neutralization capacity (bottom). All Simoa measurements were performed in duplicate.