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Representative simulated plasma and lung mAb concentration‐time profile. Physiologically‐based pharmacokinetic model output depicting the differential mAb concentration‐time profile expected in plasma and lung tissue over 28 days. Data are simulated for a mAb with an AC‐SINS score of 1. Simulation assumes a 71 kg individual infused with 700 mg of antibody over 2 hours. AC‐SINS, affinity‐capture self‐interaction nanoparticle spectroscopy; mAb, monoclonal antibody.
