Table IV.
Univariate and multivariate factors associated with the probabilities of a major bleed following initiation of VV ECMO.
| Subgroup | n | Probability of major bleed % (95% CI) | P | HR (95% CI) | P | |
|---|---|---|---|---|---|---|
| Overall | 152 | 30·9 (24–39) | ||||
| Patient age (years) | <50 | 100 | 27·0 (20–37) | 0·15 | ||
| >50 | 52 | 38·5 (27–55) | ||||
| Blood group | A | 55 | 45·5 (34–61) | 0·036 | ||
| B | 25 | 32·0 (17–58) | ||||
| AB | 50 | 20·0 (11–35) | ||||
| O | 10 | 30·0 (11–82) | ||||
| Duration of mechanical ventilation (days) | <7 | 108 | 23·7 (16–36) | 0·049 | 1·00 | 0·057 |
| >6 | 44 | 38·2 (29–51) | 1·72 (0·98–3·04) | |||
| Ferritin (μg/l) | <1301 | 76 | 36·8 (27–50) | 0·083 | ||
| >1 300 | 76 | 25·0 (17–37) | ||||
| Platelets (109/l) | Below normal (<150) | 18 | 55·6 (36–86) | 0·041 | ||
| Normal (150–400) | 116 | 26·7 (20–36) | ||||
| Above normal (>400) | 18 | 33·3 (17–66) | ||||
| WBC (109/l) | Normal (4·1–11·1) | 72 | 38·9 (29–52) | 0·044 | 1·00 | 0·060 |
| Above normal (>11·1) | 80 | 23·7 (16–35) | 0·57 (0·32–1·02) | |||
| ALT (IU/l) | Normal (8–40) | 57 | 40·4 (29–56) | 0·054 | ||
| Above normal (>40) | 95 | 25·3 (18–36) | ||||
| Bilirubin (µmol/l) | Normal (0–20) | 108 | 35·2 (27–46) | 0·082 | ||
| Above normal (>20) | 44 | 20·5 (11–37) | ||||
| CRP (mg/l) | <240 | 76 | 23·7 (16–36) | 0·051 | ||
| >239·9 | 76 | 38·2 (29–51) |
ALT, alanine aminotransferase; CRP, C reactive protein; VV ECMO, veno‐venous extracorporeal membrane oxygenation;WBC, white blood cells.
Values in bold are significant.