Table 4.
Non-expansion States | Expansion States | Unadjusted | Adjusted | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
2011–12 | 2015–16 | AD | RC (%) | 2011–12 | 2015–16 | AD | RC (%) | DID | p value | DID | p value | |
All patients (n) | 1,972 | 1,847 | 1,311 | 1,568 | ||||||||
All stages | ||||||||||||
Median survival (months)# | 6.51 (6.21–6.93) |
8.18 (7.16–9.07) |
7.20 (6.60–7.89) |
9.72 (8.41–11.10) |
||||||||
1-year survival (%) | 28.70 | 53.55 | 24.85 | 86.59 | 33.26 | 58.29 | 25.03 | 75.26 | 0.19 | 0.94 | −1.85 | 0.41 |
2-year survival (%) | 12.27 | 40.01 | 27.74 | 226.04 | 15.56 | 43.62 | 28.06 | 180.34 | 0.32 | 0.88 | −0.83 | 0.69 |
Stage I-III | ||||||||||||
Median survival (months)# | 11.47 (10.48–12.42) |
13.77 (12.75–15.54) |
13.04 (11.7–15.15) |
16.89 (14.62–19.09) |
||||||||
1-year survival (%) | 46.62 | 67.67 | 21.04 | 45.14 | 51.69 | 70.09 | 18.40 | 35.60 | −2.64 | 0.47 | −3.27 | 0.37 |
2-year survival (%) | 21.53 | 46.94 | 25.41 | 117.98 | 26.40 | 50.57 | 24.17 | 91.52 | −1.24 | 0.72 | −1.45 | 0.68 |
Stage IV | ||||||||||||
Median survival (months)# | 3.38 (3.15–3.84) |
3.80 (3.40–4.47) |
3.91 (3.45–4.40) |
4.93 (4.11–5.95) |
||||||||
1-year survival (%) | 13.56 | 42.19 | 28.62 | 211.03 | 18.58 | 47.78 | 29.20 | 157.13 | 0.58 | 0.85 | −0.54 | 0.86 |
2-year survival (%) | 4.65 | 34.23 | 29.58 | 635.56 | 5.90 | 37.13 | 31.23 | 529.28 | 1.65 | 0.52 | 0.82 | 0.75 |
AD=absolute difference (in %); DID=difference-in-differences; RC=relative change (% change between time periods). Median overall survival presented with 95% confidence intervals.
Statistically significant difference (p<0.05) in median overall survival between non-expansion and expansion states for each time period.