Table 1.
Baseline demographic and preoperative variables in R and BR PDAC patients who received NAT and underwent curative-intent pancreaticoduodenectomy.
| Variable | Overall cohort (n = 273) |
Event ≤6 months (n = 64) |
Event >6 month/no recurrence (n = 209) |
P-value |
|---|---|---|---|---|
| Age, yrs | 65 (58–72) | 65 (55–73) | 66 (59–71) | 0.259 |
| Male gender | 136 (50) | 35(55) | 101 (48) | 0.373 |
| White race | 263 (96) | 63 (98) | 200 (96) | 0.461 |
| BMI, kg/m2 | 26 (23–30) | 26 (23–30) | 27 (23–30) | 0.339 |
| ASA class | ||||
| 1 | 1 (0.4) | 0 (0) | 1 (0.5) | |
| 2 | 33 (13) | 2 (3) | 31 (15) | 0.080 |
| 3 | 214 (81) | 56 (90) | 158 (78) | |
| 4 | 16 (6) | 4 (7) | 12 (6) | |
| CCI (age-adjusted) | 5(4–5) | 4(4–5) | 5(4–6) | 0.347 |
| Radiologic stage at diagnosis | ||||
| Resectable | 78 (29) | 62 (30) | 16 (25) | 0.470 |
| Borderline resectable | 195 (71) | 147 (70) | 48 (75) | |
| EUS size, cm | 2.8 (2.3–3.4) | 3 (2.5–3.5) | 2.8 (2.3–3.4) | 0.135 |
| CT size, cm | 2.9 (2.2–3.5) | 3.2 (2.7–3.8) | 2.8 (2.1–3.3) | 0.002 |
| Vessel involvement | 201 (73.9) | 49 (76.6) | 152 (73.1) | 0.579 |
| None | 71 (26.1) | 15 (23.4) | 56 (26.9) | |
| Venous | 155 (57) | 33 (51.6) | 122 (58.7) | 0.157 |
| Arterial | 10 (3.7) | 2 (3.1) | 8 (3.9) | |
| Venous and arterial | 36 (13.2) | 14 (21.9) | 22 (10.6) | |
| Type of NAT | ||||
| Gemcitabine based | 211 (77) | 47 (73) | 164 (79) | |
| 5-FU based | 45 (17) | 11 (17) | 34 (16) | 0.531 |
| Crossover | 13 (4.8) | 5 (7.8) | 8 (3.8) | |
| Other | 4 (1.5) | 1 (1.6) | 3 (1.4) | |
| Number of NAT cycles | 3 (2–4) | 3 (2–5) | 3 (2–4) | 0.719 |
| Neoadjuvant radiotherapy | 101 (37) | 28 (44) | 73 (35) | 0.201 |
| CA19–9 level, U/ml | ||||
| Pre-NAT | 201 (54–626) | 472 (75–1469) | 153 (49–413) | 0.001 |
| Post-NAT | 43 (15–136) | 71 (20–320) | 39 (14–100) | 0.005 |
Variables are presented as medians (interquartile range) and raw numbers (percentage). BMI: body mass index, ASA: American Society of Anesthesiology score, CCI: Charlson-comorbidity index, EUS: endoscopic ultrasound, CT: computed tomography, NAT: neoadjuvant treatment