Table 1.
Chemical properties of anti-tuberculosis drugs.
| Molecular mass (g/mol) | pKa (strongest acidic/basic) | LogP | Solubility* (mg/ml) | Stability** |
|||
|---|---|---|---|---|---|---|---|
| Room temp. (hours) | Freeze/thaw cycles | Freezer (weeks) | |||||
| Rifampicin | 823.0 | +6.80/+7.37 | +2.95 | 2.70 × 10−3 | 4–12 [45], [47], [48] | yes [45], [47] | 4 [45], [47], [48] |
| Isoniazid | 137.1 | +13.6/+3.35 | −0.690 | 5.34 × 101 | 4–12 [45], [47], [48] | yes [45], [47] | 4 [45], [47], [48] |
| Ethambutol | 204.3 | +14.8/+9.55 | −0.0600 | 1.26 × 102 | 4–12 [45], [47], [48] | yes [45], [47] | 4 [45], [47], [48] |
| Pyrazinamide | 123.1 | +13.1/−0.550 | −1.23 | 4.49 × 102 | 4–12 [45], [47], [48] | yes [45], [47] | 4–12 [45], [47], [48] |
| Levofloxacin | 361.4 | +5.29/+6.16 | +0.510 | 2.01 × 100 | 6 [48] | NA | 4–12 [48] |
| Moxifloxacin | 401.4 | +5.49/+9.42 | −0.500 | 3.20 × 10−1 | 6 [48] | NA | 4–12 [48] |
| Bedaquiline | 555.5 | +13.6/+8.91 | +7.13 | 1.01 x10−5 | 72 [55] | yes [55] | >1 year [55] |
| Linezolid | 337.4 | +14.9/−1.18 | +0.64 | 2.29 × 10−1 | 6 [48] | NA | 4 [48] |
| Clofazimine | 473.4 | NA/+6.63 | +7.30 | 2.64 × 10−5 | 6 [48] | NA | 4 [48] |
| Cycloserine | 102.1 | +4.21/+8.36 | −2.42 | 1.06 × 102 | 6 [48] | NA | 4–12 [48] |
| Terizidone | 302.3 | −0.65/+4.46 | −0.56 | 9.57 × 10−2 | 6 [48]*** | NA | 4–12 [48]*** |
| Delamanid | 534.5 | NA/+5.51 | +6.14 | 6.86 x10−6 | NA | yes [62] | 780 days [62] |
| Imipenem | 317.4 | +3.44/+11.8 | −3.80 | 1.96 × 100 | 4 [64] | no [64] | 10 days [64] |
| Meropenem | 383.5 | +3.28/+9.39 | −4.35 | 1.76 × 100 | 24 [64] | yes [64] | 20 days to 6 months [64], [65] |
| Amikacin | 585.6 | +12.2/+9.61 | −8.58 | 1.49 × 103 | 6 [48] | NA | 4–12 [48] |
| Streptomycin | 581.6 | +10.9/+11.5 | −7.49 | 2.44x102 | 4–12 [45], [47], [48] | yes [45], [47] | 4–12 [45], [47], [48] |
| Ethionamide | 166.2 | +11.89/+5.00 | +1.33 | 1.81 × 100 | no [48] | NA | no [48] |
| Prothionamide | 180.3 | +8.19/+7.25 | +1.94 | 6.18 × 10−1 | no [48] | NA | 4 [48] |
| PAS | 153.1 | +3.68/+2.19 | +0.83 | 1.85 × 101 | 6 [48] | NA | 4 [48] |
| Amoxicillin | 365.4 | +3.23/+7.22 | −2.31 | 1.63 × 10−2 | 6 [48] | NA | 4–12 [48] |
The chemical properties molecular mass, pKa, logP and solubility are calculated [88]. References in the table are only for stability assessments. *In water, **within 15% of nominal concentrations [41], [42], autosampler stability is not included as it is based on the properties of the prepared sample (e.g. acidic, methanolic, aqueous) and for details we refer to the original publication, ***tested as cycloserine. PAS = p-aminosalicylic acid, NA = not available.