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. Author manuscript; available in PMC: 2021 Dec 8.
Published in final edited form as: Biomed Pharmacother. 2021 Mar 23;138:111503. doi: 10.1016/j.biopha.2021.111503

Fig. 5.

Fig. 5.

Glycyrrhizin (GLY) reduces activities of bone resorptive cathepsin B and K in the calvarium lesions of aged mice induced by PMMA particles. Expression patterns of cathepsin B and K mRNA (A, D) and in situ molecular imaging of cathepsin B and K activities (B, E) in the PMMA particle-induced calvarial lesions of wild type aged (twenty-four-month-old) mice that received: Control (no particles), PMMA particles alone, and PMMA/GLY injection. The levels of signal intensity of cathepsin B (C) and cathepsin K (F) with respect to total flux quantified from the molecular imaging assay. *p < 0.05, **p < 0.01, ***p < 0.001.