Table 3.

Median NLR across levels of each lifestyle factor examined. A detailed description of each variable can be found in Table 1.

Factor ¹	Level	N (level)	N (factor)	NLR median [IQR]	p-val ²

Ever Smoker	Yes	20,596	45,131	2.04 [1.24]	<2.2E-16
	No	24,494		1.93 [1.12]
	Refused/Don’t know	41		1.79 [1.12]

Alcohol use I (drinking days per year)	None	7,988	35,335	2.06 [1.30]	<2.2E-16
	≤ 10	7,995		1.96 [1.16]
	> 10 and ≤ 50	7,209		1.95 [1.13]
	> 50 and ≤ 100	3,838		1.95 [1.11]
	> 100	8,263		2.01 [1.18]
	Refused/Don’t know	42		2.43 [1.26]

Alcohol use II (drinks per drinking day)	1	9,586	27,346	2.00 [1.19]	2.91E-06
	2 or 3	11,295		1.94 [1.12]
	4 or 5	3,205		1.96 [1.13]
	> 5	3,220		1.99 [1.14]
	Refused/Don’t know	40		2.04 [1.30]

BMI	≤ 18.5	914	47,175	1.91 [1.30]	0.008 p-trend: 5.39E-05
	> 18.5 and ≤ 25	14,285		1.95 [1.21]
	> 25 and ≤ 30	15,676		1.96 [1.14]
	> 30	16,300		2.00 [1.16]

Physical Activity	None	14,627	28,029	1.99 [1.20]	<2.2E-16
	Moderate only	7,136		1.95 [1.11]
	Vigorous only	2,257		1.79 [0.99]
	Moderate and vigorous	4,001		1.84 [0.99]
	Refused/Don’t know	8		1.69 [0.43]

Vigorous Activity Duration	≤ 1 hour	4,025	6,248	1.84 [0.97]	0.19
	> 1 hour and ≤ 2 hours	1,575		1.78 [1.01]
	> 2 hours and ≤ 4 hours	575		1.80 [1.02]
	> 4 hours	72		1.94 [1.01]
	Refused/Don’t know	1		3.62 [0.00]

Moderate Activity Duration	≤ 1 hour	8,564	11,115	1.91 [1.05]	0.13
	> 1 hour and ≤ 2 hours	1,624		1.89 [1.04]
	> 2 hours and ≤ 4 hours	764		1.99 [1.19]
	> 4 hours	159		1.98 [1.01]
	Refused/Don’t know	4		1.63 [0.42]

Time sitting/reclining	≤ 1 hour	4,371	27,992	1.88 [1.04]	1.67E-07 p-trend: 2.99E-09
	> 1 hour and ≤ 2 hours	12,820		1.93 [1.14]
	> 2 hours and ≤ 4 hours	9,789		1.96 [1.16]
	> 4 hours	903		2.00 [1.11]
	Refused/Don’t know	109		2.00 [1.17]

Vegetable intake (servings per day)	0	152	1,509	2.11 [1.12]	0.43
	1 or 2	1,163		2.10 [1.31]
	3 or 4	177		2.22 [1.17]
	> 4	12		2.74 [1.39]
	Refused/Don’t know	5		1.93 [1.44]

Fast food (meals per week)	0	5,559	17,309	1.96 [1.16]	0.007 p-trend: 0.02
	> 0 and ≤ 5	10,283		1.95 [1.13]
	> 5 and ≤ 10	1,107		1.94 [1.11]
	> 10	357		1.84 [1.12]
	Refused/Don’t know	3		0.99 [0.50]

Detailed descriptions of all factors can be found in Table 1

p values for difference in median NLR between factor levels: calculated using Mann Whitney test for 2 levels and Kruskal Wallis omnibus test for >2 levels. P-trend obtained from Jonckheere-Terpstra test for ordered differences among levels.