Table 3.

Predictive and discriminatory performance of blood pressure measures for cardiovascular disease.

Cardiovascular disease events	C-statistic (95% CI)	Category-free NRI (SE)	IDI (SE)
Systolic BP
Year-15 systolic BP	0.69 (0.65–0.73)	Reference	Reference
Systolic BP change	0.60 (0.56–0.65)	0.22, p = 0.001	0.001, p = 0.40
Cumulative systolic BP	0.72 (0.69–0.76)	0.40, p < 0.0001	0.02, p = 0.002
Diastolic BP
Year-15 diastolic BP	0.66 (0.62–0.70)	Reference	Reference
Diastolic BP change	0.58 (0.53–0.62)	0.10, p = 0.15	0.001, p = 0.35
Cumulative diastolic BP	0.70 (0.66–0.74)	0.29, p < 0.0001	0.02, p < 0.0001
Pulse Pressure
Year-15 pulse pressure	0.59 (0.56–0.4)	Reference	Reference
Pulse pressure change	0.56 (0.51–0.60)	0.05, p = 0.48	0.0001, p = 0.87
Cumulative pulse pressure	0.59 (0.55–0.63)	0.08, p = 0.22	0.002, p = 0.11

CI: confidence interval; SE: standard error; BP: blood pressure; NRI: net reclassification index; IDI: integrated discrimination improvement.