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miR-425-5p enhanced osteoporosis in mice. A miR-425-5p level in the MSC. B The protein level of ANXA2 in MSC. C protein level of MT1-MMP in MSC. D BMD level of femurs. E The concentration of osteocalcin in serums. F ALP activities in serums. Data from 3 independent replicates were expressed as mean ± standard deviation (SD) values.n = 3,*P < 0.05, **P < 0.01 vs control or sham; # P < 0.05, ## P < 0.01 vs osteoporosis model + NC-mimics
