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. 2021 Dec 8;21:343. doi: 10.1186/s12911-021-01693-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Reproducibility validation flow diagram showing how the AD cohort and UD cohort are used to validate the original AD clustering in different datasets: (1) splitting AD cohort into trial and test set, (2) using trial set to cluster patients using a cluster method, (3) split training set into a decision tree training and cross validation, then train a decision tree, (4) label test sets with trained decision tree (gold standard labels), (5) repeat cluster method, (6) find % discordance between decision tree labels and cluster labels to quantify reproducibility. AD Alzheimer's disease, UD unspecified dementia