Fig. 9.

The proposed regulation way of circCDC14A in acute phase of stroke. After tMCAO modeling, the elevation of circCDC14A in plasma was prior to that in peri-infarct cortex. Elevated circCDC14A were mainly located in neutrophils peripherally and astrocytes centrally. Through the impaired blood–brain barrier, neutrophils were important medium for peripheral and central delivery of circCDC14A. Knocking down the expression of circCDC14A peripherally changed the phenotype of infiltrated neutrophils from N1 to N2 and relieved astrocytes activation, which helps to decrease infarct volume, neurological deficit and increase survival rate in acute phase of tMCAO modeling