Table 2.

Vital sign changes during the study period. SBP: Systolic Blood Pressure; DBP: Diastolic Blood Pressure; VAS: Visual Analogue Scale; POSAS: Patient and Observer Scar Assessment Scale

Vital sign	Placebo (N = 32)	Timolol (N = 32)	P -value	P -value ( repeated measure ANOVA)
SBP (mmHg)				0.021
Base line	112.1 ± 9.7	111.2 ± 10.5	0.748
Day 1	112.8 ± 8.5	108.5 ± 10.4	0.097
Day 2	113.2 ± 9.8	106.7 ± 8.3	0.007
Day 3	111.5 ± 8.8	107.1 ± 10.1	0.065
Day 4	112.9 ± 9.4	107.8 ± 9.0	0.024
DBP (mmHg)				0.070
Base line	70.4 ± 7.9	71.2 ± 9.0	0.883
Day 1	71.8 ± 7.8	68.5 ± 7.0	0.081
Day 2	72.1 ± 8.3	67.5 ± 7.1	0.021
Day 3	71.2 ± 7.5	67.5 ± 8.0	0.065
Day 4	72.1 ± 7.9	69.0 ± 6.8	0.089
Body Temperature (°C)				0.188
Base line	37.1 ± 0.4	37.0 ± 0.4	0..888
Day 1	36.9 ± 0.3	36.8 ± 0.3	0.328
Day 2	36.9 ± 0.4	36.6 ± 0.3	0.002
Day 3	36.8 ± 0.3	36.8 ± 0.4	0.389
Day 4	36.7 ± 0.3	36.7 ± 0.3	0.388
Respiratory Rate (n/min)				0.007
Base line	16.5 ± 2.9	17.7 ± 2.5	0.066
Day 1	17.9 ± 1.5	18.3 ± 0.8	0.091
Day 2	17.6 ± 1.2	18.4 ± 0.9	0.008
Day 3	17.3 ± 1.6	18.3 ± 0.6	0.006
Day 4	17.6 ± 1.2	18.2 ± 0.8	0.051
Heart Rate (n/min)				0.716
Base line	79.3 ± 7.1	81.8 ± 4.5	0.050
Day 1	80 ± 4.0	78.4 ± 3.0	0.115
Day 2	79.9 ± 3.8	78.6 ± 2.2	0.089
Day 3	79.3 ± 3.5	79 ± 2.0	0.884
Day 4	79 ± 3.6	78.4 ± 2.0	0.514