Table 3.
Clinical efficacy and safety variables. VAS: Visual Analogue Scale; VSS: Vancouver Scar Score; POSAS: The Patient and Observer Scar Assessment Scale
| Parameter |
Placebo
(N = 32) |
Timolol
(N = 32) |
P -value | P -value ( repeated measure ANOVA) |
|---|---|---|---|---|
| VAS | <0.001 | |||
| Day 1 | 6.75 ± 2.1 | 5.09 ± 2.1 | 0.004 | |
| Day 2 | 5.53 ± 1.8 | 1.09 ± 1.4 | <0.001 | |
| Day 3 | 4.31 ± 1.7 | 0.18 ± 0.5 | <0.001 | |
| Day 4 | 3.5 ± 1.8 | 0.09 ± 0.2 | <0.001 | |
| Day 7 | 0.96 ± 1.1 | 0.03 ± 0.1 | <0.001 | |
| Day 14 | 0.09 ± 0.2 | 0 | 0.078 | |
| Healing Time, Day | 14.5 ± 3.2 | 11.5 ± 2.3 | <0.001 | - |
| Graft Rejection, N | 3 | 0 | - | - |
| Infection, N | 0 | 0 | - | - |
| POSAS, Patient | 4.78 ± 1.5 | 4.18 ± 1.2 | 0.12 | - |
| POSAS, Observer | 3.68 ± 1.1 | 3.15 ± 1.1 | 0.06 | - |
| VSS, Month 3 | 4.75 ± 1.9 | 3.34 ± 1.8 | 0.005 | - |