Table 1.
Incidence of pathological changes in liver tissues of SD rats with/without EGCG pre-treatment after being injected APAP for 8 h
| Histopathology | EGCG (mg/kg) | No. of Rat | Degrees of pathological changes | ||||
|---|---|---|---|---|---|---|---|
| APAP (mg/kg) | Total (250+500+1000) | ||||||
| 0 | 250 | 500 | 1000 | ||||
| - ± + ++ | - ± + ++ | - ± + ++ | - ± + ++ | - ± + ++ | |||
| Centrilobular hypertrophy | 0 | 6 | 6 0 0 0 | 3 2 1 0 | 0 2 3 1* | 0 1 2 3* | 3 5 6 4* |
| 100 | 6 | 6 0 0 0 | 4 2 0 0 | 3 2 1 0* | 1 3 2 0* | 8 7 3 0# | |
| Ganuloma | 0 | 6 | 6 0 0 0 | 4 1 1 0 | 1 1 3 1* | 0 1 3 2* | 5 3 7 3* |
| 100 | 6 | 6 0 0 0 | 5 1 0 0 | 4 1 1 0 | 2 3 1 0 | 11 5 1 0# | |
-: none; ±: extremely slight; +: slight; ++: moderate. *p < 0.05, based on the Fisher's exact test, and significantly different from the corresponding group exposed to 0 mg/kg APAP; #p < 0.05, based on the Fisher's exact test, and significantly different from the corresponding group exposed to 0 mg/kg EGCG.