Table 3.

Experimental matrix of D-optimal mixture design and observed responses

	Component 1	Component 2	Component 3	Response 1	Response 2
Experience number	A: Oleic Acid%	B: Tween ® 20%	C: Transcutol ® P%	Particle size (nm)	PDI
1	10	34	56	352.73	0.559
2	8.64004	51.261	40.099	160.9	0.282
3	6.5	57.2885	36.2115	66.97	0.492
4	6.5	34	59.5	154.8	0.317
5	10	70	20	154.56	0.489
6	8.11183	70	21.8882	18.87	0.172
7	10	41.801	48.199	189.73	0.305
8	10	70	20	164.36	0.397
9	6.5	39.2781	54.2219	135.46	0.461
10	8.64004	51.261	40.099	132.2	0.216
11	6.5	65.9117	27.5883	18.2	0.307
12	6.5	34	59.5	163.2	0.301
13	10	34	56	312.76	0.489
14	6.5	47.1868	46.3132	155.83	0.592
15	8.11183	70	21.8882	18.49	0.188
16	10	59.7325	30.2675	161.96	0.301