Table 5.
Univariable and multivariable odds ratios for different risk factors for a CIN2+ diagnosis in 2000–2016 for women with IBD.
| IBD cohort | CIN2+ | CIN2+ | ||
|---|---|---|---|---|
| Univariable | Multivariable | |||
| OR | 95% CI | OR | 95% CI | |
| Screening episodes in a 5-year period | ||||
| 1 episode | 1.00 | Ref | 1.00 | Ref |
| >1 episode | 1.64 | 1.08–2.48 | 2.00 | 1.16–3.44 |
| >2 episodes | 3.26 | 1.60–6.62 | 5.02 | 1.89–13.35 |
| Urbanisation | ||||
| Low level | 1.00 | Ref | 1.00 | |
| High level | 1.43 | 0.96–2.13 | 1.41 | 0.81–2.44 |
| Disease type | ||||
| UC | 1.00 | Ref | 1.00 | 1.00 |
| CD | 1.39 | 0.90–2.13 | 0.96 | 0.61–1.53 |
| Age at diagnosis | ||||
| ≥25 years | 1.00 | Ref | 1.00 | Ref |
| <25 years | 1.60 | 1.09–2.36 | 1.54 | 0.91–2.59 |
| CD behaviour | ||||
| B1 | 1.00 | Ref | ||
| B2, B3 or all p | 0.79 | 0.49–1.26 | ||
| CD location | ||||
| L1 or L2 | 1.00 | Ref | 1.00 | Ref |
| L3 or all L4 | 1.92 | 1.14–3.24 | 1.84 | 1.05–3.24 |
| UC extent | ||||
| E1 or E2 | 1.00 | Ref | ||
| E3 | 0.67 | 0.31–1.45 | ||
| Education level | ||||
| Low | 1.00 | Ref | 1.00 | Ref |
| High | 0.77 | 0.51–1.15 | 0.63 | 0.37–1.09 |
| Smoking status | ||||
| No | 1.00 | Ref | 1.00 | Ref |
| Yes | 2.59 | 1.74–3.86 | 3.20 | 1.90–5.40 |
| Exposure to immunomodulators | ||||
| No | 1.00 | Ref | 1.00 | Ref |
| <1 year | 0.42 | 0.18–0.99 | 0.37 | 0.13–1.09 |
| >1 year | 0.89 | 0.59–1.33 | 0.91 | 0.54–1.55 |
| Exposure to biologics | ||||
| No | 1.00 | Ref | ||
| <1 year | 0.72 | 0.36–1.47 | ||
| >1 year | 0.96 | 0.61–1.54 | ||
Bold numbers: statistically different.
CIN, cervical intraepithelial neoplasia; CIN2+, CIN2 or higher grade of neoplasia; IBD, inflammatory bowel disease; OR, odds ratio, CI, confidence interval; CD, Crohn’s disease; B, behaviour; L, location; UC, ulcerative colitis, E, extent; p, perianal disease; Ref, reference value.