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. 2021 Dec 1;35(23-24):1551–1578. doi: 10.1101/gad.348866.121

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© 2021 Phan and Holland; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 2. — Centrosome biogenesis cycle. G1 cells contain a single centrosome comprising a pair of centrioles surrounded by the pericentriolar material (PCM). The mature parent centriole is decorated with distal and subdistal appendages, while the immature centriole lacks these structures. In S phase, a single procentriole forms on both parent centrioles. Throughout S and G2 phases, the procentrioles elongate, and in late G2, the two centrosomes separate and undergo PCM expansion. During mitosis, the two centrosomes act to catalyze the assembly of the bipolar microtubule spindle apparatus on which chromosomes are segregated. The mature parent centriole can also dock at the cell membrane and initiate the assembly of a primary cilium in early G1 in the case of dividing cells, or during G0 phase in quiescent cells.