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. 2021 Dec 1;35(23-24):1551–1578. doi: 10.1101/gad.348866.121

Figure 3.

Figure 3.

The molecular genetics of primary microcephaly. (A) Genes implicated in MCPH and MPD classified by functional group and subcellular localization. (B) Schematic of representative centrosome and spindle proteins mutated in microcephaly. Protein domains and regions of interactions are depicted based on studies by Gillingham and Munro (2000), Kohlmaier (2009), Carvalho-Santos et al. (2010), Hatch et al. (2010), Holland et al. (2010), Van Breugel et al. (2011), Issa et al. (2013), Kim et al. (2013), Lin et al. (2013), Sonnen et al. (2013), Arquint et al. (2015), Mori et al. (2015), Chen et al. (2017), and Patwardhan et al. (2018). (SMC-A/B) Structural maintenance of chromosomes (SMC)-like domain A/B, (PBD) polo-box domain, (CR1/2) conserved region 1/2, (CC) coiled-coil region, (STAN) Stil/Ana2 domain, (PISA) present in SAS-6, (TCP) T complex protein 10 domain, (CH) calponin homology domain, (MBD) MKK7β1 binding domain, (JBD) JNK binding domain, (LHD) loop helix domain.