TABLE 2.

ERG11 hot spot region amino acid variations between C. auris, C. albicans, C. krusei, and C. glabrata^a

^aAmino acid resides within ERG11 hot spot regions which are associated with fluconazole resistance in C. albicans and which vary between C. auris and C. albicans are shown as compared to the corresponding residues in C. krusei and C. glabrata. Amino acid variations associated with fluconazole resistance in C. auris and studied in this work are shown in bold and highlighted in green. Additional amino acid varying between the Candida species shown which match variations associated with resistance in C. albicans are shown in bold and highlighted in blue. The length of peptide sequence corresponding to hot spot 3 in C. albicans varies among the Candida species shown. The C. albicans V437 residue in this region is shown underlined.