FIG 5.

Genotype-phenotype network connections illustrating phenotypic basis of S. Typhimurium genetic factors required for enteric infection (in vitro versus in vivo [enteric]). Large square nodes indicate various conditions (studies), and small nodes are fitness genes. Each node (gene) is shared by at least one of the in vitro conditions (i.e., stressors encountered by Salmonella during enteric infection; PA, pH 3, NaCl, bile, and LB42; current study and our previous study) and at least one of the in vivo enteric conditions (pig, calf, and chicken; a previous study). The interactive network through the network data exchange (NDEx) is available at www.ndexbio.org/#/network/027b067d-e209-11e8-aaa6-0ac135e8bacf (118).