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Schematic representation of bioprinting using a co-axial nozzle. Two strategies are possible: (A) the bioink is extruded sheathed by a solution of the crosslinking agent, resulting in the formation of a solid fiber; (B) the bioink is extruded sheathing a solution of the crosslinker, resulting in the formation of a hollow hydrogel fiber. Figure reproduced from Reference (Costantini et al., 2018).
