Table 2. Anterograde projection sites of AVPV/PeN CRFR1 neurons.
Regions were assigned the following scores to indicate relative label densities: - no label; −/+ minimal labeling; + moderate density; ++ dense labeling; +++ very dense labeling. Ratings are based on labeling patterns from 4 female mice. OVLT; organum vasculosum of the lamina terminalis, BNST; bed nucleus of the stria terminalis, AVPV; anteroventral periventricular nucleus.
| Brain Region | Fiber Density |
|---|---|
| Prelimbic cortex | - |
| Infralimbic cortex | - |
| Lateral Septum (ventral) | ++ |
| Medial Septum | + |
| Medial Preoptic Area | +++ |
| AVPV | +++ |
| OVLT | +++ |
| BST (dorsolateral) | ++ |
| BST (anteroventral) | +++ |
| BST (principal nucleus) | ++ |
| Paraventricular Hypothalamus | +++ |
| Dorsomedial Hypothalamus | +++ |
| Ventromedial Hypothalamus | + |
| Anterior Hypothalamus | + |
| Lateral Hypothalamus | + |
| Supraoptic Nucleus | ++ |
| Tuberal Nucleus | ++ |
| Arcuate Nucleus | ++ |
| Paraventricular thalamus | + |
| Basolateral Amygdala | - |
| Central Amygdala | −/+ |
| Medial Amygdala | + |
| Cortical Amygdala | - |
| Periaqueductal Gray | + |
| Ventral Tegmental Area | + |
| Locus Coeruleus | + |
| Dorsal Tegmental Area | - |
| Barrington’s Nucleus | + |
| Parabrachial Nucleus | + |
| Mammillary (principal) | - |
| Dorsal Raphe | + |
| Median Raphe | - |