Supplementary Table 4.

Multivariate Cox regression analysis on association between plasma IL-6 level and stroke and all-cause mortality in patients with AF

Variable	Stroke		All-cause mortality
	HR (95% CI)	P-value	HR (95% CI)	P-value
Age (years)	2.06 (1.08, 3.90)	0.027*	3.10 (1.70, 5.67)	0.001*
<65	Reference		Reference
65~74	1.55 (0.41, 5.84)	0.519	2.41 (0.67, 8.68)	0.180
≥75	4.22 (1.23, 14.54)	0.022*	8.91 (2.64, 30.03)	0.001*
Comorbidity
Diabetes	3.34 (1.13, 9.82)	0.029*	-	-
Coronary disease	-	-	1.10 (0.45, 2.64)	0.833
Heart failure	-	-	5.41 (1.99, 14.65)	0.001*
Stroke	2.11 (1.21, 3.70)	0.009*	-	-
IL-6 (pg/mL)
≤55.2	Reference		Reference
>55.2	3.81 (1.11, 13.05)	0.033*	3.11 (1.25, 7.72)	0.015*

^*P<0.05, the difference was statistically significant; - unavailable.

Cox proportional hazards model for stroke adjusted for age, types of AF, history of diabetes and history of stroke; for all-cause mortality, adjusted for age, types of AF, history of coronary disease and history of heart failure; using a backward selection strategy.

AF - atrial fibrillation; CI - confidence interval; HR - hazard ratio; IL - interleukin