Scheme 1. (A) Synthesis of tetrameric macrocycles via N-tBu deprotection of dimer 1a–d to afford 2a–d, and cascade dimerisation-cyclisation under Buchwald–Hartwig conditions. (B) Single crystal X-ray structures of 1a and 2a, sidechains are highlighted in green and red. (C) Synthetic scope of tetrameric macrocycle formation.
