Substrate scope of mono-defluorinative alkylations^a,b.

^aReaction conditions: 1 (0.1 mmol), 2 (0.2 mmol), Pd-PEPPSI-Hept (5.0 mol%), NaOH (0.2 mmol), THF (1.0 mL), 100 °C, 1 h under N₂, isolated yields.

^bCs₂CO₃ used instead of NaOH.

^cThe diastereomeric ratio was determined by ¹H NMR analysis of the crude mixtures.

^dCoupling at CH₃/CH ratio.

^eAcetone (0.5 mmol).