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. Author manuscript; available in PMC: 2022 May 10.
Published in final edited form as: Nat Struct Mol Biol. 2021 Nov 10;28(11):923–935. doi: 10.1038/s41594-021-00677-4

Figure 7. Interaction modes and impact of CTD lysine residues on RNA polymerase II CTD and FUS domain interactions.

Figure 7.

A) Comparison of the dominant interaction modes between residues within SYGQ LC11-54 and RNAP21853-1896 (left) or RGG454-501 and RNAP21853-1896 (right) in decreasing order of normalized contact frequency among residue types present 3 or more times in the sequences. B) Quantification of partitioning of AlexaFluor labeled RNA polymerase II CTD variants (or positive control SYGQ LC, left) into either FUS SYGQ LC or ΔSYGQ LC droplets. Data are plotted as mean ± s.d. of measurements from n=3 replicates in one representative data set out of two independent experiments.