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. 2021 Dec 8;16(12):e0260878. doi: 10.1371/journal.pone.0260878

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© 2021 Artelt et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 3 — (A) Immunofluorescence staining of kidney sections shows a reduced expression of the slit membrane protein nephrin in PodoPalld129-/- mice compared with corresponding controls. Scale bar represents 20 μm. (B) Transmission electron micrographs (arrows) and (C) scanning electron micrographs (asterisks) revealed strongly effaced podocyte foot processes in PodoPalld129-/- mice. Scale bars represents 1 μm. (D) Quantification of foot process area confirmed the increased podocyte foot process effacement in 6 months as wells as 12 months old PodoPalld129-/- mice compared with corresponding controls. Data are represented as violin plot (**** p<0.0001; two-way ANOVA with FDR correction).