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. 2021 Nov 24;12:732324. doi: 10.3389/fmicb.2021.732324

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Copyright © 2021 Janssen, de Almeida, Damasceno, Baptista, Pappas, de Campos and Martins.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representation of group I NTE_KPCs gene clusters and its flanking genome contexts. This analysis was created with GCluster using different Klebsiella pneumoniae genomes, found in the literature, and the genomes of the strains KpV3 and Kp31. The blaKPC gene is represented in blue, the insertion sequences ISkpn6 are colored in purple and it is located downstream the blaKPC gene, as in most NTE_KPCs. The insertion sequence IS26 is represented in pink and is located upstream the blaKPC, but in the KpV3 this IS26 sequence is found in an opposite orientation when compared to the other group I NTE_KPCs.