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. Author manuscript; available in PMC: 2022 Aug 1.
Published in final edited form as: Nano Today. 2021 Jun 19;39:101223. doi: 10.1016/j.nantod.2021.101223

Figure 3. pH-responsive nanoparticles target NK1R in the endosome to target chronic pain.

Figure 3.

A) Structure of pH-responsive DIPMA and pH-non-responsive BMA nanoparticles. The nanoparticles share the same hydrophilic shell, P(PEGMA-co-DMAEMA), but have different hydrophobic cores. B) Accumulation of nanoparticles in spinal neurons, the target of the encapsulated Aprepitant. C) pH-responsive nanoparticles target NK1R in endosomes. D) DIPMA-Aprepitant (AP) nanoparticles are more effective than morphine in mouse models of inflammatory pain [98].