Skip to main content
. 2021 Nov 17;10:e72919. doi: 10.7554/eLife.72919

Figure 7. Insulin-induced copeptin and glucagon secretion is diminished in people with type 1 diabetes.

Figure 7.

(a) Hypoglycemia was induced by an insulin infusion in patients with T1D (n=10) and non-diabetic individuals (Controls; n=10). The insulin infusion was initiated at 0 min. (b) Plasma glucagon during the clamping period. Two-way RM ANOVA by both factors. Indicated time point versus 0 min; p<0.01=††. Between groups; p<0.05=*. Data from n=10 Control and n=10 T1D. (c) Plasma copeptin measurement during and following clamping period. Change in copeptin from baseline (time=0 min). Two-way RM ANOVA by both factors. Time point versus 0 min; p<0.001=†††; ns = not significant (p>0.05). Between groups; p<0.001=***. Data from n=10 Control and n=10 T1D. (d) Correlation of copeptin and glucagon following hypoglycemic clamping for control participants (n=10, circle) and T1D (n=10, square). Linear regressions (dashed lines) for Control and T1D data sets.