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. 2021 Dec 6;28(1):2582–2593. doi: 10.1080/10717544.2021.2009936

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© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Preliminary safety evaluation of the biomimetic nanosystem. (A) Cell viability of HUVEC cells incubated for 24 h with different concentration of empty NLCs and MM-NLCs (n = 3, mean ± SD). (B) Hemolysis assay of empty formulations. 0.9% (w/v) sodium chloride solution and double distilled water were served as the negative and positive control, respectively (n = 3, mean ± SD, ***p < .001). (C) Histological staining of organs from healthy mice treated with different CEP-load formulations (scale bar = 100 μm).