Table 3.

Model statistical summary of all applied models for vesicle size and entrapment efficiency.

Source	Std. Dev.	R 2	Adjusted R2	Predicted R2	PRESS	Remark
Vesicle size (Y1)
Linear	23.32	0.8259	0.7943	0.72679	18786.54
2FI	16.53	0.9363	0.8966	0.79256	14264.05
Quadratic	2.92	0.9985	0.9968	0.99239	523.6022	Suggested
Entrapment efficiency (Y2)
Linear	1.46	0.9776	0.9734	0.9679	66.70
2FI	1.17	0.9895	0.9830	0.9800	41.53
Quadratic	0.51	0.9984	0.9967	0.9916	17.34	Suggested