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Proposed schematic representation of the effect of paracetamol and NSAIDs on body temperature. The paracetamol-induced hypothermia under normothermia (Panel A) and febrile conditions (Panel B) is proposed to be mediated through the inhibition of a hypothalamic COX-1 variant enzyme. Most NSAIDs are non-hypothermic (Panel C), but are able to reduce febrile temperature through inhibition of inducible hypothalamic COX-2 enzyme
