Fig. 4.

Adjusted values of SPACE-MS metrics for all study centres. This figure shows the age-, sex-, disease-duration-, and lesion-load-adjusted values of SPACE-MS metrics for all 16 study centres. Overall, such adjusted values of SPACE-MS metrics were very similar across centres. Importantly, though, the values shown in this figure have not been adjusted for disability measures, so the variability across centres due to differences in disability scores between centres has not been removed. Abbreviations: CAI: covariance anisotropy index; CPI: covariance planarity index; CSI: covariance sphericity index; NCI: neuraxis caudality index.