Fig. 5.

Baseline associations between spatial distribution metrics and clinical variables. This figure shows the main associations between spatial distribution metrics and clinical variables at baseline, after adjusting for all relevant confounders. For graphical purposes only, the y-axis in this figure indicates the values of the clinical variable at baseline (dependent variable) after having been adjusted for all the covariates in the corresponding ‘best a priori model’ (as indicated in the methods and Table 3). Abbreviations in alphabetical order: CSI: covariance sphericity index; EDSS: expanded disability status scale; NCI: neuraxis caudality index; NHPT: nine-hole peg test; PASAT: paced auditory serial addition test; SDMT: symbol digit modalities test; TWT: 25-foot timed walk test.