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. 2021 Nov 20;23:560–570. doi: 10.1016/j.omto.2021.11.010

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© 2021 The Author(s)

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

HPLC assays confirmed that the increase of SLC22A4 promoted cellular imatinib uptake of CML cells

(A) Preparing different concentrations (0.4, 1, 2, 4, and 8 μM) of imatinib to draw a standard curve. High-performance liquid chromatography peak maps are shown above. (B) The standard curve was drafted according to the area of the peak map, and the R² value of 0.999 approaches 1. (C) The relative content of imatinib in SOS1-knockdown cells increased in K562 and KCL-22 cells. (D) Diagram showing the relationship of SOS1 with SLC22A4. Data are presented as mean ± SD obtained from at least three independent experiments. Significance was determined using one-way ANOVA; ∗p < 0.05, SOS1-siRNA#3 versus NC.