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. 2021 Dec 6;74:103730. doi: 10.1016/j.ebiom.2021.103730

Figure 5.

Figure 5

Both environmental and genetic factors significantly modified the POE of mQTLs on cg18036618. a). top:cg18036618 was regulated by the POE of the mQTL rs117020124. bottom: the POE of rs117020124 was modified by lifetime smoking status. The contrast in methylation levels of cg18035618 between heterozygotes of the mQTL rs117020124 is largest in current smoker group. b). top:cg18036618 was regulated by the POE of the mQTL rs117823351. bottom: the POE of rs117823351 was modified by ‘predicted mRNA expression level of SIRT1’. The contrast in methylation levels of cg18035618 between heterozygotes of the mQTL rs117823351 is larger in individuals with low SIRT1 expression. High/low expression: participants with predicted expression levels larger than the median were categorized as the high group.