Table 1.

Genetic/environmental modifiers displaying a significant interaction with the POE(mQTL) and the CpGs the interaction effects affect.

mQTL-CpG-modifer trio information								Discovery					Replication
CpG: id	CpG-chr	CpG-POS	mQTL:id	mQTL- chr	mQTL- POS	Modifier	Modifier type	P(dis,t-test)	Est(dis)	N(dis)	P(trio-specific, permutation)	Adjusted P(trio-specific. permutation)	P(rep)	Est(rep)	N(rep)	Adjusted P(rep, t-test)
cg22592140	7	130132419	rs142053217	7	130258926	mRNA expression of KDM1A	Genetic	1.35E-06	6.35	1607	1.00E-05	1.09E-02	6.09E-04	6.52	645	2.79E-02
cg21252175	15	64973903	rs111834387	15	64062211	mRNA expression of TET2	Genetic	1.54E-06	3.77	1607	<1e-5	< 0.01	7.76E-11	13.80	647	2.43E-08
cg18035618	20	57415978	rs117020124	20	57347435	Lifetime smoking status	Env	9.94E-07	-0.04	1607	<1e-5	< 0.01	1.42E-03	-0.05	647	4.85E-02
			rs117823351	20	57369773	mRNA expression of SIRT1	Genetic	3.68E-10	-0.24	1607	<1e-5	< 0.01	1.01E-03	-0.22	646	3.95E-02

CpG-POS/mQTL-POS: genomic position of the CpG and mQTL(hg19). Env: environmental modifier. dis: discovery sample, rep: replication sample. N: sample size. P(dis, t-test)/P(rep, t-test) and Est(dis)/Est(rep): P values (t test) and coefficients for the POE_mQTL x Modifier effect in the interaction model in discovery/replication samples. P(trio-specific, permutation): P value for the POE_mQTL x Modifier effect from the mQTL-CpG-modifer trio-specific permutation test. Adjusted P (trio-specific, permutation): adjusted P(trio-specific, permutation) using Bonferroni method(Text s3). Adjusted P(rep, t-test): adjusted P(rep, t-test) for interaction effect at replication dataset using the FDR method. Genomic position of the significant genetic modifiers: KDM1A: chr1: 23345941-23410182; TET2: chr4: 106067,032-106200973; SIRT1: chr10: 69644427-69678147.