Table 2.
SNPs that significantly interact with POE (POEmQTL x SNP) and the regulated CpGs
| mQTL-CpG |
SNP modifier |
Discovery |
Replication |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|
| CpG: id | mQTL: id | SNP id | Relation to G modifier | P(dis, t-test) | Adjust_P(dis,t-test) | Est(dis) | N(dis) | P(rep,t-test) | Est(rep) | N(rep) |
| cg22592140 | rs142053217 | rs75667410_T | SNP used in predict KDM1A exp | 1.35E-06 | 6.75E-06 | 0.18 | 1607 | 6.09E-04 | 0.18 | 645 |
| cg21252175 | rs111834387 | rs11729069_G | SNP used in predicting TET2 exp | 1.05E-08 | 5.25E-08 | 0.18 | 1607 | Not enough data* | ||
| rs7661349_T | 3.51E-02 | 1.76E-01 | -0.06 | 1607 | Not significant in Discovery sample | |||||
| cg18035618 | rs117823351 | rs932658_A | SNP used in predict SIRT1 exp | 3.69E-09 | 1.85E-08 | -0.07 | 1607 | 4.33E-03 | -0.06 | 646 |
| rs3740053_G | 1.55E-04 | 7.75E-04 | -1.00E-01 | 1607 | 6.01E-03 | -0.10 | 646 | |||
dis: discovery sample, rep: replication sample. N: sample size. P(dis, t-test)/P(rep, t-test) and Est(dis)/Est(rep): P values (t-test) and coefficients for the POEmQTL x SNP interaction in the interaction model in discovery/replication samples. Adjust_P(dis, t-test): Bonferroni method adjusted P(dis, t-test). *, due to the relatively small minor allele frequency (MAF) of rs111834387(MAF=0.01) and the limited sample size of replication sample, there was not enough data for this test in replication samples. Number of individuals within heterozygous groups available for testing POE(rs111834387) x SNP(rs11729069) interaction effect on cg21252175 in replication samples were shown in Table s11.