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. 2021 Nov 25;12:724361. doi: 10.3389/fimmu.2021.724361

Figure 4.

Figure 4

Molecular modeling of C2 and C2b. (A) Three-dimensional model of full C2 sequence built by homology modeling using Factor B structure (PDB code 2XWB) as a template. C2b domain in orange, VWA domain in green, SP domain in red, residues 243–250 in blue, and residues 249 and 250 in spheres representation. (B) Three-dimensional structure of C2a (PDB code 2I6Q). VWA domain in green, SP domain in red, residues 243–250 in blue, and residues 249 and 250 in spheres representation. (C) Close-up view of VWA domain and part of domain C2b from the complete structure of C2 protein [see (A)], color code as used in (A), moreover residues 288 and 460 are shown in yellow. (D) Close-up view of VWA domain from C2a structure [see (B)] with residues 288 and 460 shown in yellow.