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. 2021 Dec 8;11:23622. doi: 10.1038/s41598-021-01655-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Visualization of the CLANS analysis results. Each panel shows the graphical two-dimensional representation of each dataset. Nodes represent the sequences in the analyzed dataset. Each sequence set includes the related domain and the corresponding homologous sequences derived from HMM profiling. The clusters are the results of the network-based clustering function of the CLANS software. The upper panel shows the clustering analysis from full-length sequences, and other panels are clusters from just the identified domain (labeled on the bottom left of each group). The nodes are colored based on the number of clusters (color key at bottom right). The sequence of Sgp_SARS-CoV-2 or its domains is involved in cluster 1 in each group, except for the N-terminal domain (NTD); which is not involved in any cluster. The details of the clusters are summarized in Table 2.