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. 2021 Dec 8;11:23622. doi: 10.1038/s41598-021-01655-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Combination of sequence bundle plot with sequence logo and correspondence scattered plot. The top left panel was initiated with different amino acids sorted by their chemical properties. Additionally, the top panel displays every sequence in the alignment as an individual continuous line, whose shapes correspond to the residues of that sequence. Multiple sequences that have the same residue are stacked on top of each other, thereby forming a thick bundle (conserved site). The sequence logo of the alignment section is also presented below the bundles and is followed by a color-coded sequence of Sgp_SARS-CoV-2. The top left section shows the correspondence analysis scattered plot. Sequences are shown as green circles and sites as blue crosses. The Sgp_SARS-CoV-2 sequence and nearby sites are selected (red colors). The selected sites (shown in red color) are mirrored in the sequence of Sgp_SARS-CoV-2 at the lower panel (black boxes). Residues Thr500 and Asn501 are identified as significantly associated with Sgp_SARS-CoV-2. The lower left is a zoom-in view of the selected site.