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. 2021 Dec 8;12(12):1140. doi: 10.1038/s41419-021-04427-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Heatmap shows correlation between the gene modules and clinical traits. Each cell contains the corresponding correlation and p value. B The Module Membership (MM) versus Gene Significance (GS) scatterplot for GBM with IDH wildtype in turquoise or yellow module. Each dot represents a gene, and the red lines were set as a threshold for Module Membership > 0.8 and Gene Significance > 0.2. C The proportion of candidate hub genes in the turquoise and yellow modules. D GO (BP) and KEGG enrichment annotation of candidate hub genes in turquoise or yellow module. GO gene ontology, BP biological process. In the network diagram, the roman number residing in each circle represents a functional term; values on each line indicate number of overlap genes between terms. E Key regulated upstream transcription regulators (TFs) of candidate hub genes in module by TRRUST. F Hub genes were selected based on overlap between co-expression network and STRING analysis. G Univariate Cox regression results for the 14 genes in the CGGA dataset. H Coefficient values of the five selected genes by LASSO.